Biochemical and Histopathological evaluation of prostatic tissue under effect of Pterostilbene in benign prostatic hyperplasia rat model

Background: Benign prostatic hyperplasia [BPH] is the urologic condition that affects elderly men most frequently hyperplasia. must be distinguished from
 lower urinary tract symptoms and benign enlargement. which refers to an enlarged prostate, a purely histological term development, maintenance, secretory activity of prostate other sex-accessory tissues are stimulated by presence certain hormones growth factors. pathophysiology significantly influenced enzyme 5α-reductase. It's important remember 5-αreductase responsible for creating Dihydrotestosterone stronger androgen. Pterostilbene Mostly found in blueberries grapes pterostilbene substance with number biological properties including anticancer properties. lipid-soluble molecule exists both cis trans forms latter being more prevalent. The conventional medication utilized this trial was finasteride inhibits 5α-reductase lowers amount Dihydrotestosterone.
 Methods: Forty-eight male rats were divided into six groups; control group consisted eight who received subcutaneous injections oil vehicle period 42 days. induction testosterone propionate fourteen 0.44 mg/kg oral gavage twenty-eight days following 200 included 8 given 200mg/kg 28 after 14 induction. 100 100mg/kg per day kg dose resveratrol After days.
 Results: Histological section similar those negative revealed numerous variable sizes alveoli filled homogenous eosinophilic secretion, had normal epithelial stromal tissue.
 Conclusion: have potent anti-proliferative effect decrease hyperplastic nodules return cell very good scavenging free radical [very as antioxidant] compare Vitamin c resveratrol.
 Aim study: evaluate Anti proliferative on assess antioxidant DPPH Assay.